The KDIGO Controversies Conference on the Role of Complement in Kidney Disease was held in Florence, Italy from Thursday, September 29 to Sunday, October 2, 2022. This conference gathered a global panel of multidisciplinary clinical and scientific expertise (i.e., pediatrics, rheumatology, complement basic research, renal pathology, genetics) and a motivated group of patient representatives to define the role of complement in a spectrum of kidney diseases including glomerular disorders and diabetic nephropathy.

For each disease that was addressed, the evidence indicating whether complement plays a primary or secondary role in their etiologies was reviewed. The value of biomarkers of complement activity in monitoring disease course and whether specific drivers (i.e., genetic or acquired) dysregulate complement activity was also critically examined, as was the potential impact/role of the glomerular microenvironment in contributing to the complement response.

The KDIGO Controversies Conference on the Role of Complement in Kidney Disease was be co-chaired by Richard Smith (USA), and Marina Vivarelli (Italy).

 

PLENARY PRESENTATIONS

State of the Art
Giusseppe Remuzzie

aHUS and C3G
David Kavanaugh

Systemic Diseases with Complement Involvement in the Kidney: SLE, APL, AAV
Andreas Kronbichler

Glomerular Diseases in which Complement is Emerging as a Driver of Injury: IgAN, MN, FSGS, Diabetic Nephropathy Defined
Carla Nester

KDIGO Role of Complement in Kidney Disease Patient & Caregiver Panel