In KDIGO 2024 Guideline on ANCA-Associated Vasculitis: Reading Between the Lines, guideline Co-Chair Brad Rovin, MD (United States), and Geetha Duvuru, MD (United States) review the latest KDIGO guidance using case-based studies, including discussion on indications for plasma exchange and avacopan, to showcase challenging patient scenarios and illustrate the optimal application of guideline recommendations and practice points.