The Kidney Disease: Improving Global Outcomes (KDIGO) 2017 Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of chronic kidney disease–mineral and bone disorder (CKD-MBD) represents a selective update of the prior guideline published in 2009.
This update, along with the 2009 publication, is intended to assist the practitioner caring for adults and children with CKD, those on chronic dialysis therapy, or individuals with a kidney transplant. Specifically, the topic areas for which updated recommendations are issued include diagnosis of bone abnormalities in CKD-MBD; treatment of CKD-MBD by targeting phosphate lowering and calcium maintenance, treatment of abnormalities in parathyroid hormone in CKD-MBD; treatment of bone abnormalities by antiresorptives and other osteoporosis therapies; and evaluation and treatment of kidney transplant bone disease.
Development of this guideline update followed an explicit process of evidence review and appraisal. Treatment approaches and guideline recommendations are based on systematic reviews of relevant trials, and appraisal of the quality of the evidence and the strength of recommendations followed the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach. Limitations of the evidence are discussed, with areas of future research also presented.
The guideline was co-chaired by Markus Ketteler, MD, FERA (Klinikum Coburg, Germany) and Mary Leonard, MD, MSCE (Stanford University School of Medicine, United States).
IMPLEMENTATION TOOLS
VIDEOS
COMMENTARIES
Canadian Society of Nephrology
European Renal Best Practice
Endorsement of the 2009 KDIGO Chronic Kidney Disease–Mineral and Bone Disorder (CKD-MBD) Guidelines
KDOQI
US Commentary on the 2017 KDIGO Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease–Mineral and Bone Disorder (CKD-MBD)
US Commentary on the 2009 KDIGO Clinical Practice Guideline for the Diagnosis, Evaluation, and Treatment of CKD–Mineral and Bone Disorder (CKD-MBD)
Nature Reviews Nephrology
KDIGO 2017 CKD–MBD guideline update: evolution in the face of uncertainty
United Kingdom Renal Association
How do the 2009 KDIGO Clinical Practice Guidelines on CKD – MBD apply to the UK?
2017 CKD-MBD Guideline Update Translations
Chinese (Mandarin)
2017 KDIGO 临床实践指南更新 慢性肾脏病-矿物质与骨异常 (CKD-MBD) 诊断, 评估, 预防和治疗
Japanese
KDIGO 2017 CKD-MBD推奨文和訳版
Korean (Executive Summary)
2017년 KDIGO 만성 콩팥병-미네랄뼈질환 가이드라인 업데이트: 변경 사항과 주요 시사점
Turkish (Executive Summary)
Böbrek Hastalıkları: KDIGO Kronik Böbrek Hastalıgı-Mineral ve Kemik Bozuklukları (KBH-MKB) Kılavuzu 2017 Güncellemesi’nin Idari Özeti: Yapılan Degisiklikler ve Bunların Önemi
2009 CKD-MBD Guideline Translations
Arabic
Chinese (Mandarin)
KDIGO 慢性肾脏病－矿物质和骨异常诊断、评价、预防和治疗的临床实践指南
French
German
Greek
Italian
Japanese
CKD-MBD の診断、検査法、予防および治療に関するKDIGO 診療ガイドライン
Portuguese
Russian
Spanish
Turkish
DISCLAIMER: USE OF THE CLINICAL PRACTICE GUIDELINES
This Clinical Practice Guideline is based upon the best information available at the time of publication. The recommendations are designed to provide information and assist decision-making. They are not intended to define a standard of care, and should not be construed as one. Neither should they be interpreted as prescribing an exclusive course of management. Variations in practice will inevitably and appropriately occur when clinicians take into account the needs of individual patients, available resources, and limitations unique to an institution or type of practice. Every health care professional making use of this Guideline is responsible for evaluating the appropriateness of applying them in the setting of any particular clinical situation. The recommendations for research contained within this document are general and do not imply a specific protocol.
