Level 1 recommendations are strong recommendations for clinical practice, indicating that most people would want the recommended course of action, and only a small proportion would not. These recommendations begin with “We recommend.”

Level 2 recommendations indicate that the majority of people would want the recommended course of action, but many would not, meaning that the approach should be individualized, utilizing a shared decision-making process, as different choices will be appropriate for different patients. These recommendations begin with “We suggest.”