KDIGO develops its clinical practice guidelines through a rigorous, evidence-based process in line with international best practices for guideline development. The steps include:

• Topic Selection: Prioritizing topics based on disease burden, prevalence, and potential impact on patient outcomes
• Work Group Formation: Assembling a diverse group of experts with clinical, research, and methodological expertise, as well as people with lived experience, ensuring multidisciplinary and geographic representation
• Scope of Work Development: Crafting the key clinical questions to be addressed by a particular guideline. Scope of Work documents are made available for Public Review. 
• Evidence Review: Conducted based on rigorous reviews of the best available scientific evidence in line with international standards for systematic reviews, evidence synthesis, and guideline development utilizing the GRADE approach
• Drafting Recommendations: Developing graded recommendations considering the balance of benefits and harms; certainty of the evidence; patient values and preferences; resource use and costs; and considerations for implementation, and complementing these recommendations with consensus-based practice points, infographics, and future research recommendations 
• Public Consultation: Soliciting feedback from stakeholders and the public to ensure the guidelines are comprehensive, valid, and applicable
• Finalization and Publication: Revising the draft based on feedback and publishing the final guidelines for implementation

To learn more about KDIGO Guideline methodology, please refer to the KDIGO Methods Manual.